RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-154
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
P15
Pathway
WNT SIGNALING PATHWAY
PubMed ID
Title
Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload
Year
2016
Function
"Treatment with lna-antimiR-154 in a setting of pressure overload was able to i) maintain cardiac function, ii) attenuate hypertrophy (increases in heart and cardiomyocyte size), iii) improve expression of cardiac pathology markers, and iv) prevent a significant increase in cardiac fibrosis."